pipeline pilot v7.5 (Accelrys)
90
Structured Review
Accelrys
pipeline pilot v7.5
Pipeline Pilot V7.5, supplied by Accelrys, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/pipeline+pilot+(v7%2E5/pipeline+pilot+version+7+5/ppr0693549-162-6-9
Average 90 stars, based on 1 article reviews
Pipeline Pilot V7.5, supplied by Accelrys, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/pipeline+pilot+(v7%2E5/pipeline+pilot+version+7+5/ppr0693549-162-6-9
Average 90 stars, based on 1 article reviews
pipeline pilot v7.5 - by Bioz Stars,
2026-09
90/100 stars
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Generated:Article Title: Design, synthesis and biological activities of piperidine-spirooxadiazole derivatives as α7 nicotinic receptor antagonists. Article Snippet: a: 7 nicotinic acetylcholine receptors (nAChRs) expressed in the nervous and immune systems have been suggested to play important roles in the control of inflammation.. However, the lack of antagonist tools specifically inhibiting a7 nAChR impedes the validation of the channel as therapeutic target.. To discover a selective a7 antagonist, we started a pharmacophore-based virtual screening and identified a piperidine-spirooxadiazole derivative T761e0184 that acts as a a7 antagonist. Article Title: Identification and characterization of benzo[d]oxazol-2(3H)-one derivatives as the first potent and selective small-molecule inhibitors of chromodomain protein CDYL. Article Snippet: Chemical probes of epigenetic ‘readers’ of histone post-translational modifications (PTMs) have become powerful tools for mechanistic and functional studies of their target proteins in physiology and pathology.. However, only limited ‘reader’ probes have been developed, which restricted our understanding towards these macromolecules and their roles in cells or animals.. Here, we reported a structure-guided approach to develop and characterize benzo [d]oxazol-2(3H)-one analogs as the first potent and selective small-molecule inhibitors of chromodomain Y-like (CDYL), a histone methyllysine reader protein. Article Title: Small-molecule compounds targeting the STAT3 DNA-binding domain suppress survival of cisplatin-resistant human ovarian cancer cells by inducing apoptosis. Article Snippet: In brief, the database was prepared by using a homemade protocol in Article Title: Discovery of novel multidrug resistance protein 4 (MRP4) inhibitors as active agents reducing resistance to anticancer drug 6-Mercaptopurine (6-MP) by structure and ligand-based virtual screening Article Snippet: The compound database was prepared with an in-house protocol developed in Article Title: Tumor-resident microbiota contributes to colorectal cancer liver metastasis by lactylation and immune modulation Article Snippet: All compounds were rst treated with Article Title: Bisphenol AF promotes inflammation in human white adipocytes Article Snippet: Images were analyzed using custom algorithms developed with the Selection:Article Title: Design, synthesis and biological activities of piperidine-spirooxadiazole derivatives as α7 nicotinic receptor antagonists. Article Snippet: a: 7 nicotinic acetylcholine receptors (nAChRs) expressed in the nervous and immune systems have been suggested to play important roles in the control of inflammation.. However, the lack of antagonist tools specifically inhibiting a7 nAChR impedes the validation of the channel as therapeutic target.. To discover a selective a7 antagonist, we started a pharmacophore-based virtual screening and identified a piperidine-spirooxadiazole derivative T761e0184 that acts as a a7 antagonist. Article Title: Identification and characterization of benzo[d]oxazol-2(3H)-one derivatives as the first potent and selective small-molecule inhibitors of chromodomain protein CDYL. Article Snippet: Chemical probes of epigenetic ‘readers’ of histone post-translational modifications (PTMs) have become powerful tools for mechanistic and functional studies of their target proteins in physiology and pathology.. However, only limited ‘reader’ probes have been developed, which restricted our understanding towards these macromolecules and their roles in cells or animals.. Here, we reported a structure-guided approach to develop and characterize benzo [d]oxazol-2(3H)-one analogs as the first potent and selective small-molecule inhibitors of chromodomain Y-like (CDYL), a histone methyllysine reader protein. Article Title: Small-molecule compounds targeting the STAT3 DNA-binding domain suppress survival of cisplatin-resistant human ovarian cancer cells by inducing apoptosis. Article Snippet: In brief, the database was prepared by using a homemade protocol in Article Title: Discovery of novel multidrug resistance protein 4 (MRP4) inhibitors as active agents reducing resistance to anticancer drug 6-Mercaptopurine (6-MP) by structure and ligand-based virtual screening Article Snippet: The compound database was prepared with an in-house protocol developed in Article Title: Tumor-resident microbiota contributes to colorectal cancer liver metastasis by lactylation and immune modulation Article Snippet: All compounds were rst treated with Article Title: Bisphenol AF promotes inflammation in human white adipocytes Article Snippet: Images were analyzed using custom algorithms developed with the |